RAF Typhoon FGR4s have joined forces with France's air force in a combined operation on an subterranean weapons facility in Syrian territory operated by the Islamic State group (IS), per a report from the UK's MoD.
The location, pinpointed through reconnaissance, was believed to be containing munitions and bombs, the statement said, and was situated in mountainous terrain just north of the historic site of Palmyra in the heart of Syria.
"The RAF jets used laser-guided Paveway IV weapons to target a several access tunnels leading to the depot... preliminary assessments indicate the target was engaged successfully," the ministry announced.
There was no indication of any civilian impact in the strike late on Saturday and all the aircraft returned to base without incident, the defence officials confirmed.
The Typhoon FGR4s were supported by a Voyager refuelling tanker.
The Islamic State group - also known as Daesh - enforced jihadist rule over significant areas in both Syria and Iraq before its territorial defeat in 2019.
"This action underscores our UK leadership, and determination to stand shoulder to shoulder with our allies, to eliminate any resurgence of Daesh and their violent and radical beliefs in the Middle East," the British Defence Secretary John Healey said.
UK warplanes have carried out patrols over Syria to "forestall any attempted comeback" of the group following its military defeat at the battle of Baghuz in the year 2019, the ministry said.
"I want to thank all the members of the UK armed forces participating in this operation for their professionalism and their courage," the Defence Secretary said. "They were part of thousands of UK service members deployed over the festive period. This action, to remove terrorist threats who pose a risk to our security, demonstrates how our armed forces are always on standby, continuously, ensuring Britain's security within its borders and influential overseas."
Last December, the American forces executed what it called a "major assault" against Daesh sites in Syria, subsequent to an ambush killed two US servicemembers and a civilian interpreter in Palmyra.
The United Nations says IS still has between 5,000 and 7,000 militants in both countries.